Contributing factors for the development of metabolic syndrome, may include obesity, insulin resistance, polycystic ovary disease, hormone imbalance or a sedentary, unhealthy (smoking, etc.) lifestyle. “Over nutrition” and poor dietary choices (highly processed, high fat, high salt, high sugar “empty-calorie” foods), combined with sedentary habits interact with our genetic programming: we store extra calories as fat. Fat cells (adipocytes) produce hormones (adipokines) that interact with the hypothalamus and or immune system and may have pro-inflammatory or anti-inflammatory effects. Altered adipokine levels have been observed in Metabolic syndrome.
The biomarkers that constitute the Metabolomic Profile include:
Hemoglobin A1c (HbA1c) – estimates the average blood glucose concentration for
the life of the red blood cell (120 days)
Insulin – levels of insulin elevate early in type II diabetes, and then decrease as pancreatic beta cells lose function
High sensitivity C-reactive protein (hs-CRP) – estimates the risk of cardiovascular disease
Leptin – leptin is a hormone produced by adipocytes to provide a satiety signal to the hypothalamus. Elevated circulating levels of leptin are associated with adipose tissue abundance, and a leptin resistance may ensue. High levels of this adipokine may have pro-inflammatory effects, and leptin accelerates arterial foam cell formation.
*Adiponectin – improves insulin sensitivity and stimulates glucose
uptake in adipocytes, and adiponectin has been shown to reduce lipid
accumulation in foam cells in vitro. Very low levels of this
anti-inflammatory adipokine may increase the risk for certain cancers
*Leptin to Adiponectin ratio- the ratio of leptin to adiponectin appears to be a sensitive indicator for a variety of health conditions.
(* markers only available in the full blood test (CMI40), not the finger-prick test).
Metabolomic Profile Blood Spot (CMI39)
Test Type:Blood (Dried Blood Spot)
Turn Around Time: 14 days.