Description
ENVIROtox Panel includes Great Plains Organic Acids Test (OAT), GPL-Tox and Glyphosate. (Not Mycotoxin)
Please be aware that currently the GPL-TOX element of this test/profile is temporarily unavailable due to hardware issue in the lab!
All urine samples will remain stable in the GPL freezers, testing samples will begin immediately and will be processed in the order received, you should expect first your test results in the next 2-3 weeks. The GPL-TOX Profile remains the only test affected by these issues. While GPL expect to have all markers back in operation, we cannot provide a date at this time.
You will continue to see the five analytes listed below on your GPL-TOX Profile report, with no result reported.
• 3 - 3MHA (11% historical positivity)
• 9 - HEMA (6% historical positivity)
• 12 - NAE (13% historical positivity)
• 13 - NADB (1% historical positivity)
• 14 - DMP (19% historical positivity)
In most instances other analytes on this test may provide equivalent insight into clinical concerns related to possible toxic exposures and clinical manifestations.
Great Plains Organic Acid Test includes 76 urinary metabolites that provide a comprehensive snapshot of a patient’s overall health as the initial screening test and is useful for discovering underlying causes for chronic illness.
The GPL-TOX screens for 172 different environmental pollutants using 18 different metabolites from a single urine sample including organophosphate pesticides, phthalates, benzene, xylene, vinyl chloride, pyrethroid, insecticides, acrylamide, perchlorate, diphenyl phosphate, ethylene oxide, acrylonitrile and more. The profile also includes Tiglylglycine (TG), a marker for mitochondrial disorders resulting from mutations of mitochondrial DNA. These mutations can be caused by exposure to toxic chemicals, infections, inflammation and nutritional deficiencies. The GPL-TOX uses advanced mass spectrometry (MS/MS) which is necessary to detect lower levels of certain genetic, mitochondrial and toxic chemical markers that conventional spectrometry often miss. It pairs perfectly with other Great Plains Laboratory tests to assess for exposure to common environmental toxins. These include the Organic Acids Test (OAT) and the Glyphosate Test. Exposure to environmental pollutants has been linked to many chronic diseases.
Glyphosate is the world’s most widely produced herbicide. It kills weeds by targeting the enzymes that produce the amino acids tyrosine, tryptophan and phenylalanine. It can enter the body directly through the skin, eating treated foods or drinking contaminated water. It is known to disrupt the microbiome of many animals, including humans and consequently has been related to metabolic disorders, diabetes, depression, autism, cardiovascular disease and autoimmune conditions. Recent studies have also correlated exposure to glyphosate with many chronic health problems including hypertension, stroke, diabetes, obesity, intestinal infections, dementia, Parkinson’s, MS, inflammatory bowel disease, renal disease and cancer.
Methodology
Advanced mass spectrometry combined with liquid chromatography (LC/MS/MS)
When should I use
When environmental toxicity is suspected.
Chronic illnesses including heart disease, chronic fatigue syndrome, chemical sensitivity, autism spectrum disorders, ADD/ADHD, autoimmune disorders, Parkinson’s disease, and Alzheimer’s disease.
Other Details
Consider ENVIROtox Complete Panel if you need to assess for Mycotoxins as well.
