Description
Please be aware that currently the GPL-TOX element of this test/profile is temporarily unavailable due to hardware issue in the lab!
All urine samples will remain stable in the GPL freezers, testing samples will begin immediately and will be processed in the order received, you should expect first your test results in the next 2-3 weeks. The GPL-TOX Profile remains the only test affected by these issues. While GPL expect to have all markers back in operation, we cannot provide a date at this time.
You will continue to see the five analytes listed below on your GPL-TOX Profile report, with no result reported.
• 3 - 3MHA (11% historical positivity)
• 9 - HEMA (6% historical positivity)
• 12 - NAE (13% historical positivity)
• 13 - NADB (1% historical positivity)
• 14 - DMP (19% historical positivity)
In most instances other analytes on this test may provide equivalent insight into clinical concerns related to possible toxic exposures and clinical manifestations.
The GPL-TOX screens for 172 different environmental pollutants using 18 different metabolites from a single urine sample including organophosphate pesticides, phthalates, benzene, xylene, vinyl chloride, pyrethroid, insecticides, acrylamide, perchlorate, diphenyl phosphate, ethylene oxide, acrylonitrile and more. The profile also includes Tiglylglycine (TG), a marker for mitochondrial disorders resulting from mutations of mitochondrial DNA. GPL-TOX test is an important tool for assessing exposure to common environmental toxins.
This test is combined with
Great Plains organic acid test includes 76 urinary metabolites that provide a comprehensive snapshot of a patient’s overall health as the initial screening test and is useful for discovering underlying causes for chronic illness.
Includes biomarkers for:
Intestinal Microbial Overgrowth
Oxalate Metabolites
Glycolytic Cycle Metabolites
Mitochondrial Makers (Kreb Cycle)
Neurotransmitter Metabolites
Folate Metabolism
Ketone and Fatty Acid Oxidation
Nutritional Markers
Indicators of Detoxification
Amino Acid Metabolites
Organic acids are chemical compounds excreted in the urine that are products of metabolism. Metabolism is the sum of chemical reactions in living beings by which the body builds new molecules and breaks down molecules to eliminate waste products and produce energy.
Organic acids are commonly analysed in urine because they are not extensively reabsorbed in the kidney tubules after glomerular filtration. Thus, organic acids in urine are often present at 100 times their concentration in the blood serum and thus are more readily detected in urine. This is why organic acids are rarely tested in blood or serum.
Methodology
Measured by a combination of gas or liquid chromatography.
When should I use
Useful for many clinical presentations including chronic illnesses, heart disease, chronic fatigue syndrome, chemical sensitivity, autism spectrum disorders, ADD/AD(H)D, autoimmune disorders, Parkinson’s disease, and Alzheimer’s disease.
Other Details
GPL01 ENVIROtox Complete Panel is a cost-effective option that includes GPL-Tox, OAT, Mycotoxins and Glyphosate
We understand that there is some discussion and no real agreement regarding challenging with glutathione before urine toxin testing. We don’t recommend this however it is a clinical decision that you may make for yourself.
However, Robyn Puglia, Clinical Support Specialist, suggests considering the following collection schedule to encourage mobilisation and elimination of toxins via urine:
The evening before the sample collection, immediately before going to bed:
First, empty the bladder, then perform full body dry body brushing followed by a hot bath with 4 cups of Epsom salts.
Then collect any urine passed from the time of getting out of the bath during the night and the first-morning void and create the sample out of the total urine collected.
