Methylation Plasma Profile

Normal methionine metabolism is absolutely critical for methylation, transsulfuration and folate-dependent transmethylation. Abnormal metabolism of methionine can be found in anyone at any age. It is usually associated with genetic or nutritional deficiencies, aging and exposures to environmental toxicants. For example, lead can inhibit methyltransferase enzymes and transmethylation of homocysteine via inhibition of the enzyme methylene-tetrahydrofolate reductase (MTHFR). This test may be useful for autism, birth defects, cancer, cardiovascular disease, congenital heart disease, impaired detoxification, Down’s Syndrome, genetic disorders, immune function, neurodegeneration and psychiatric disorders. It may also be indicated for supporting general health, longevity and nutritional deficiencies. The test results can facilitate appropriate individualised interventions to improve or normalize methionine metabolism and ameliorate or prevent adverse consequences associated with inadequate methylation and/or transsulfuration capacity.