Description
The Celiac & Gluten Sensitivity Profile (Serum) helps differentiate between Coeliac Disease, gluten sensitivity and wheat allergy by evaluating the serum titers of IgA and IgG for tissue transglutaminase, deamidated gliadin peptide, gliadin, and gluten. Wheat allergy is assessed by titers of IgE for wheat
Methodology
ChemiluminesentImmunoassay
When should I use
Patients who have persistent skin conditions (rash) or ataxia, idiopathic neurological conditions, autoimmune arthritis/ thyroiditis, unexplained weight loss or persistent gastrointestinal symptoms that are not associated with enteropathogens
Symptomatic individuals that have tested positive for the HLA DQ2/DQ8 genotypes
Patients with symptoms or symptom exacerbation with dietary gluten or re-introduction of gluten after a trial elimination of gluten
Individuals that have a first degree relative with a diagnosis of CD
Any child with a history of 3 or more antibiotic-treated cases of gastroenteritis while less than 6 months of age
Patients on a gluten-inclusive diet who have Type I diabetes, Multiple Sclerosis or schizophrenia
Individuals on a gluten-inclusive diet who have other laboratory evidence that may be associated with CD:
Elevated liver function tests
Bone demineralization
Evidence of impaired absorption of fat-soluble vitamins, iron, B12 or folic acid
Other Details
Other Tests to Consider:
IMM11A -Coeliac Profile (Finger Prick)
