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Providing you with simple, easy access to world-leading laboratories that deliver the broadest range of wellness focussed diagnostic testing services.
For health professionals and patients across the UK and around the world.

Precision Analytical - HOR30

Dutch Complete (Adrenal and Sex Hormone)

Hormones Dried Urine Turn Around Time: 12 Days
Recommended: Contact practitioner before placing order
Turn Around Time: 12 Days

Description

DUTCH Complete provides a comprehensive assessment of 35 different sex and adrenal hormones, including oestrogen, progesterone, testosterone, DHEA and cortisol along with their metabolites. It also measures daily free cortisol and cortisone patterns, the oxidative stress marker 8-OHdG, melatonin and nine organic acids including markers for vitamin B12 (methylmalonate), vitamin B6 (kynurenate and xanthurenate), biotin (β-hydroxyisovalerate), glutathione (pyroglutamate), dopamine (homovanillate), norepinephrine/epinephrine (vanilmandelate), neuroinflammation (quinolinate) and tryptophan putrefaction (indican).

Methodology

Cortisol, cortisone, 8-OHdG, melatonin (6-OHMS), organic acid tests and metabolites related to cortisol are tested by LC-MS/MS. The remaining hormones are tested by GC-MS/MS.

When should I use

DUTCH Complete can help identify the root causes of sex hormone and adrenal imbalances in both women and men. It can provide insights into conditions such as premenstrual syndrome, PMDD, PCOS, menopause, infertility, weight gain, fatigue, low libido, sleep issues and mood disorders in women. As well as infertility, weight gain, fatigue, low libido, sleep issues, mood disorders and prostate issues in men. Additionally, the test can be used to gather baseline measurements for the administration and monitoring of hormone replacement therapy.

Other Details

DUTCH Complete provides a unique assessment of sex and adrenal hormones by assessing dried urine. Urine has several advantages over both serum and saliva. It allows more effective assessment of free cortisol than serum as well as extensive metabolite testing (especially for oestrogens and cortisol). While the free cortisol pattern in saliva has clinical value, measuring cortisol metabolites in urine adds a significant missing piece, for example when cortisol clearance is abnormally high or low. Measuring oestrogen and androgen metabolites, possible in urine, gives a fuller picture for more precise clinical assessment of hormonal imbalances and (B)HRT monitoring.
Combining both sex and adrenal assessment with relevant organic acids for nutrients, neurotransmitters and detoxification as well melatonin and 8-OHdg gives further insight as to how best support the patient.
  • 16-OH-E1
  • 2-Methoxy-E1
  • 2-OH-E1
  • 2-OH-E2
  • 24 hour free cortisol
  • 24 hour free cortisone
  • 4-OH-E1
  • 4-OH-E2
  • 5-Hydroxyindolacetate (5HIAA)
  • 5a-Androstaendiol
  • 5a-DHT
  • 5b-Androstanediol
  • 8-hydroxy-2'-deoxyguanosine (8-OHdG)
  • a-Pregnanediol
  • a-Tetrahydrocortisol (a-THF)
  • Androsterone
  • b-Hydroxyisovalerate
  • b-Pregnanediol
  • b-Tetrahydrocortisone (b-THE)
  • b-Tetrahyrodcortisol (b-THF)
  • Cortisol (free) x 4
  • Cortisone (free) x 4
  • DHEA-S
  • Epi-Testosterone
  • Estradiol (E2)
  • Estriol (E3)
  • Estrone (E1)
  • Ethylmalonic
  • Etiocholanolone
  • Homovanillate (HVA)
  • Indican
  • Kynurenate
  • Melatonin
  • Metabolized cortisol (THF+THE)
  • Methylation activity (2-Me-E1 / 2-OH-E1)
  • Methylmalonic Acid (MMA)
  • Progesterone
  • Progesterone (serum equivalent)
  • Pyroglutamate
  • Quinolinate (neuroinflammation marker)
  • Testosterone
  • Total DHEA
  • Total Oestrogen (Estrogen)
  • Vanilmandelate (VMA)
  • Xanthurenate
Cycling Premenopausal Women Begin collection between days 19 and 22 of a 28-day cycle.
For longer cycles, add the number of days you usually go beyond 28 days. In a similar manner, subtract if your cycles are shorter
(example: collect days 17-20 for a 26 day cycle).

You may collect any day if only ordering the DUTCH Adrenal or
DUTCH OATs.
For irregular cycles or non-cycling (ablation or uterus removed), watch the irregular cycle collection video in the video library at dutchtest.com/videos for suggestions on collecting.

Men & Non-Cycling or Postmenopausal Women Collect any day.

HOW TO COLLECT
• Complete all information on each collection device.
• Saturate the filter paper by urinating directly on it OR use a clean cup and dip the filter paper.
Leave the collection device open to dry for at least 24 hours.
• Once dry, close each collection device. Place all devices in the resealable plastic bag and return
in the provided envelope. Be sure to include the completed requisition form (required).

WHEN TO COLLECT
While adhering to your most common wake/sleep schedule, collect as close as possible to the below timeline.
No Alcohol, Caffeine or Large Fluid Intake after lunch before collecting the dinner sample. No more than one cup
of fluids between Samples

WHAT TO AVOID
Restrictions
When Collecting DUTCH Complete™ or DUTCH OATs
Foods: Avoid avocado, bananas and fava beans for 48 hours before collecting as they may elevate the HVA organic acid result; if you do consume, please make a note on your requisition
form.
Supplements: Some supplements may impact the HVA organic acid result. If you take any of the following, please consult your provider: Tyrosine, L-Dopa, D,L-Phenylalanine (DLPA), Mucuna and
Quercetin.

FAQ
What if I miss a collection? Simply collect the sample as instructed the following day. All samples do not need to be collected in one 24-hour period.

Do I have to take the samples in the order listed? No, they can be collected in a different order.

How long can I keep the dried samples before sending them in? While hormone levels are very stable in dried samples, they should be sent back as soon as possible. If you have to wait to
send them in, place in freezer (in plastic bag) after drying.

Do I need to stop taking my hormones for this test? This test is built to test patients “on” their hormones. Our suggestion is to follow the Hormone Schedule (listed previously), and any specific
instructions given by your provider.

What if my sleep schedule is abnormal (night workers, etc.)? Collect the bedtime sample before your longest stretch of sleep, the waking sample (#3) after this sleeping period, and
sample #4 two hours later. The dinnertime sample (#1) should be collected 4-7 hours before bed.

What if I am unable to urinate at the specific time? Simply drink some fluids and go as soon as you are able.

Is DUTCH testing appropriate for children? The minimum age for testing is 12 years old. To test children under 12, DUTCH strongly recommend the DUTCH Cortisol Awakening Response (CAR)
measured with saliva.

View Details

Description

DUTCH Complete provides a comprehensive assessment of 35 different sex and adrenal hormones, including oestrogen, progesterone, testosterone, DHEA and cortisol along with their metabolites. It also measures daily free cortisol and cortisone patterns, the oxidative stress marker 8-OHdG, melatonin and nine organic acids including markers for vitamin B12 (methylmalonate), vitamin B6 (kynurenate and xanthurenate), biotin (β-hydroxyisovalerate), glutathione (pyroglutamate), dopamine (homovanillate), norepinephrine/epinephrine (vanilmandelate), neuroinflammation (quinolinate) and tryptophan putrefaction (indican).

Methodology

Cortisol, cortisone, 8-OHdG, melatonin (6-OHMS), organic acid tests and metabolites related to cortisol are tested by LC-MS/MS. The remaining hormones are tested by GC-MS/MS.

When should I use

DUTCH Complete can help identify the root causes of sex hormone and adrenal imbalances in both women and men. It can provide insights into conditions such as premenstrual syndrome, PMDD, PCOS, menopause, infertility, weight gain, fatigue, low libido, sleep issues and mood disorders in women. As well as infertility, weight gain, fatigue, low libido, sleep issues, mood disorders and prostate issues in men. Additionally, the test can be used to gather baseline measurements for the administration and monitoring of hormone replacement therapy.

Other Details

DUTCH Complete provides a unique assessment of sex and adrenal hormones by assessing dried urine. Urine has several advantages over both serum and saliva. It allows more effective assessment of free cortisol than serum as well as extensive metabolite testing (especially for oestrogens and cortisol). While the free cortisol pattern in saliva has clinical value, measuring cortisol metabolites in urine adds a significant missing piece, for example when cortisol clearance is abnormally high or low. Measuring oestrogen and androgen metabolites, possible in urine, gives a fuller picture for more precise clinical assessment of hormonal imbalances and (B)HRT monitoring.
Combining both sex and adrenal assessment with relevant organic acids for nutrients, neurotransmitters and detoxification as well melatonin and 8-OHdg gives further insight as to how best support the patient.

View Analytes

  • 16-OH-E1
  • 2-Methoxy-E1
  • 2-OH-E1
  • 2-OH-E2
  • 24 hour free cortisol
  • 24 hour free cortisone
  • 4-OH-E1
  • 4-OH-E2
  • 5-Hydroxyindolacetate (5HIAA)
  • 5a-Androstaendiol
  • 5a-DHT
  • 5b-Androstanediol
  • 8-hydroxy-2'-deoxyguanosine (8-OHdG)
  • a-Pregnanediol
  • a-Tetrahydrocortisol (a-THF)
  • Androsterone
  • b-Hydroxyisovalerate
  • b-Pregnanediol
  • b-Tetrahydrocortisone (b-THE)
  • b-Tetrahyrodcortisol (b-THF)
  • Cortisol (free) x 4
  • Cortisone (free) x 4
  • DHEA-S
  • Epi-Testosterone
  • Estradiol (E2)
  • Estriol (E3)
  • Estrone (E1)
  • Ethylmalonic
  • Etiocholanolone
  • Homovanillate (HVA)
  • Indican
  • Kynurenate
  • Melatonin
  • Metabolized cortisol (THF+THE)
  • Methylation activity (2-Me-E1 / 2-OH-E1)
  • Methylmalonic Acid (MMA)
  • Progesterone
  • Progesterone (serum equivalent)
  • Pyroglutamate
  • Quinolinate (neuroinflammation marker)
  • Testosterone
  • Total DHEA
  • Total Oestrogen (Estrogen)
  • Vanilmandelate (VMA)
  • Xanthurenate

View Instructions

Cycling Premenopausal Women Begin collection between days 19 and 22 of a 28-day cycle.
For longer cycles, add the number of days you usually go beyond 28 days. In a similar manner, subtract if your cycles are shorter
(example: collect days 17-20 for a 26 day cycle).

You may collect any day if only ordering the DUTCH Adrenal or
DUTCH OATs.
For irregular cycles or non-cycling (ablation or uterus removed), watch the irregular cycle collection video in the video library at dutchtest.com/videos for suggestions on collecting.

Men & Non-Cycling or Postmenopausal Women Collect any day.

HOW TO COLLECT
• Complete all information on each collection device.
• Saturate the filter paper by urinating directly on it OR use a clean cup and dip the filter paper.
Leave the collection device open to dry for at least 24 hours.
• Once dry, close each collection device. Place all devices in the resealable plastic bag and return
in the provided envelope. Be sure to include the completed requisition form (required).

WHEN TO COLLECT
While adhering to your most common wake/sleep schedule, collect as close as possible to the below timeline.
No Alcohol, Caffeine or Large Fluid Intake after lunch before collecting the dinner sample. No more than one cup
of fluids between Samples

WHAT TO AVOID
Restrictions
When Collecting DUTCH Complete™ or DUTCH OATs
Foods: Avoid avocado, bananas and fava beans for 48 hours before collecting as they may elevate the HVA organic acid result; if you do consume, please make a note on your requisition
form.
Supplements: Some supplements may impact the HVA organic acid result. If you take any of the following, please consult your provider: Tyrosine, L-Dopa, D,L-Phenylalanine (DLPA), Mucuna and
Quercetin.

FAQ
What if I miss a collection? Simply collect the sample as instructed the following day. All samples do not need to be collected in one 24-hour period.

Do I have to take the samples in the order listed? No, they can be collected in a different order.

How long can I keep the dried samples before sending them in? While hormone levels are very stable in dried samples, they should be sent back as soon as possible. If you have to wait to
send them in, place in freezer (in plastic bag) after drying.

Do I need to stop taking my hormones for this test? This test is built to test patients “on” their hormones. Our suggestion is to follow the Hormone Schedule (listed previously), and any specific
instructions given by your provider.

What if my sleep schedule is abnormal (night workers, etc.)? Collect the bedtime sample before your longest stretch of sleep, the waking sample (#3) after this sleeping period, and
sample #4 two hours later. The dinnertime sample (#1) should be collected 4-7 hours before bed.

What if I am unable to urinate at the specific time? Simply drink some fluids and go as soon as you are able.

Is DUTCH testing appropriate for children? The minimum age for testing is 12 years old. To test children under 12, DUTCH strongly recommend the DUTCH Cortisol Awakening Response (CAR)
measured with saliva.

View More Information

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