Description
TruAge Complete provides an objective measurement of ageing, and therefore risk of age-related disease, with over 850,000 CpG loci tested. The extensive epigenetic ageing reports and algorithms provide a comprehensive picture of biological ageing and health insights.
By lowering your biological age you can target the mechanisms that underly the ageing process.
Reports included:
Epigenetic Biological Age – your whole-body summary
Telomere Length – ageing based on cellular replication
Dunedin PACE – a speedometer for your current rate of ageing
Extrinsic Epigenetic Age – immune system impact of age
Intrinsic Epigenetic Age – ageing independent of immune system
Immune cell-type ratios and CD4:CD8 ratio
Weight Loss Response to Caloric Restriction
Methodology
The laboratory extracts DNA, quantifies the DNA, and identifies methylated sites using bisulfite conversion.
The DNA is then fragmented, amplified and resuspended.
Illumina BeadChips, with silica beads, bind to specific DNA fragments where a single nucleotide is added. An antibody designed to bind to the stain attaches to that nucleotide.
(red stain for the AT nucleotide pair, and green for the GC nucleotide.)
Over 850,000 CpG sites (spots where methylation can occur) are scanned. The
beta values of these CpGs, are then run through specialist algorithms to sort them and create an age value that reflects those patterns. This then provides the personal age, impact, and risk readouts presented in the patient’s reports.
When should I use
Health conditions, diseases and phenotypic changes which are correlated to ageing.
The TruAge test looks at Biological Age measured by methylation, as research has shown it is the #1 most accurate and most predictive measure of future disease occurrence and frailty. As a result the predictive power makes it highly useful both in research and in individual longevity/health tracking.
Other Details
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