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Diagnostics on demand.
Providing you with simple, easy access to world-leading laboratories that deliver the broadest range of wellness focussed diagnostic testing services.
For health professionals and patients across the UK and around the world.

Lab guide: Cyrex Labs

What makes Cyrex Labs unique?

Cyrex Labs is the world’s leading functional immunology lab specialising in environmentally induced autoimmunity.

What area of testing does Cyrex Labs specialise in?

The Cyrex System encompasses ELISA assessment of the immune barriers such as the gut and the blood brain barrier, the environmental triggers of autoimmunity including pathogens, foods and toxic chemicals, and auto-antibodies.

The Cyrex Systems helps you understand why essential barriers, environmental triggers and predictive autoantibodies are affecting patients' immunophenotypes.

  • Determine the underlying causes of your patients' immune condition
  • Identify barrier integrity
  • Isolate and remove environmental factors
  • Implement patient specific healthy lifestyle choices
  • Support immune resilience

How and why is Cyrex Labs a leader in autoimmunity testing?

The technical, laboratory answer to this question is that quality in every Array is of critical importance when testing each patient’s specimen. We ensure we deliver this through the below:

  • Purity of antigens: a test is only as good as the purity of it’s antigen!  Optimising this process eliminates false positive and false negatives. Cyrex uses advanced extraction and purifying techniques to ensure the purity and homogeneity of the antigens that coat the plates.

  • Individualized validation of every single antigen: the painstaking process of individual validation requires years of research and development to perfect. To achieve Cyrex quality, we validate each food antigen individually, rather than applying one arbitrarily chosen reference curve to an entire group of different foods.

  • Parallel testing: standard procedure is labs around the world is to test a percentage of their specimens in duplicate for quality control. At Cyrex, we believe that each single person deserves to trust their results are accurate and so every single specimen is tested in parallel. Only when each marker has been verified will the reports be reported.

  • Patient-centred: beyond the clinical science, Cyrex understands that what is at stake with autoimmune disease is people’s quality of life. We’re talking about years of pain and suffering, of time spent with children and grandchildren, of achieving someone’s life goals and fulfilment of dreams. We are committed to not just providing accurate, reliable test results that can be relied on to support you, the clinicians, in achieving optimal results in clinical practice, but Cyrex has also broken ground and changed the global conversation around how we think about and understand the individual with Autoimmune disease.

What is Cyrex Labs' founding story?

Cyrex was founded in 2011. Our scientific team is comprised of experts from a variety of medical and research disciplines, which bring together the latest findings from medical research and the assessment needs of today’s healthcare professionals.

Out of this collaboration, the company formed and Cyrex Lab's developed the next generation of clinical lab testing that is required to care for present-day complex maladies.

Who is Cyrex Labs leadership team?

Jean Bellin, President

Jean Bellin has 30 plus years experience in the biopharmaceutical industry, including sales, marketing, business development, mergers and acquisitions, and general management – both domestic and international. He has worked with Eli Lilly, DuPont Pharma, UCB, and Luitpold Pharmaceuticals, a wholly-owned company of Sankyo Pharmaceuticals Company Ltd.

In 2006, Jean became the President of Metagenics, a global life sciences company, where Mr. Bellin lead and grew the US and international sales, marketing and manufacturing operations of the company for four and a half years. Mr. Bellin left Metagenics in October of 2010 after its acquisition by the Alticor group, the $8.2 billion parent company of Nutrilite, the largest vitamin manufacturer in the world. 

Mr. Bellin received his bachelor’s degree in Economic, Political and Social Sciences from the Facultés Universitaires Saint Louis in Brussels.

Sadi Koksoy, Ph.D, DVM, Medical Director

Dr. Koksoy is the founder of the Clinical and Research Immunology and Flow Cytometry Core Laboratory at Akdeniz University, consisting of both Clinical and Research divisions. There he developed and validated various state-of-the-art flow cytometric and immunological tests and protocols that meet national and international regulatory standards for the immunologic assessment of transplant patients, diagnosing immunodeficiencies, autoimmune diseases, hematologic malignancies, and certain infections. He also served as the Associate Director of the Histocompatibility and Immunogenetics laboratory, which is a part of one of the largest transplantation centers in Europe.

Dr. Koksoy served as a Professor of Medical Microbiology and Immunology at Akdeniz University, School of Medicine. He received his MSc and PhD degrees in the fields of Microbiology and Immunology from Ohio State University, and his Doctor of Veterinary Medicine, from Ankara University, Turkey. He has authored/co-authored more than 50 SCI-indexed papers in scientific journals.

Mark R. Engelman, M.D, FSCM, FAARM, ABAARM, Director of Clinical Consulting,

Dr. Engelman received his BS undergraduate degree from Ohio State University. He received an M.D, degree from Ohio State College of Medicine. He was a resident in Internal Medicine at St. Joseph’s Hospital and Medical Center, Phoenix, Arizona. Dr. Engelman was an Emergency Department staff Physician at St. Joseph’s for 23 years and served as Emergency Department Director for 22 years.

Mark was Board Certified in Emergency Medicine. Dr. Engelman became fascinated about Integrative Functional Medicine. He has earned a Fellowship in Stem Cell Medicine Certification and Advanced Fellowship in Integrative Functional Medicine. He is the Founder and Director of Engelman Health Institute in Phoenix and has utilized Cyrex Labs in his practice.

Aristo Vojdani, PhD, MSc, CLS, Chief Scientific Advisor

Dr Aristo Vojdani is Cyrex’s Chief Scientific Advisor and developer of Cyrex unique and innovative tests.  His on-going research focuses on the role of environmental factors in autoimmune diseases. His pioneering research has resulted in the development of more than 300 assays for the detection of root causes.  He holds more than 16 US Patents for laboratory testing and has published more than 200 articles, the latest in the peer-reviewed journal Pathophysiology. He has written and co-authored several books on the role of foods in autoimmune diseases and the gut-brain connection.

Presently, Dr Vojdani is an Adjunct Associate Professor in the Department of Preventive Medicine at Loma Linda University in California, USA. He lectures at scientific and medical conferences around the world, contributing knowledge and understanding of the complex role of the exposome in the diagnosis and management of autoimmune diseases.

What lab processes do you have in place to ensure that your tests are accurate, reliable and consistent?

Quality assurance is so important to our company, that we pride ourselves on the 4 Pillars, as above, as the bedrock of everything we do.

What national legislation does Cyrex Labs operate under?

Cyrex is CLIA certified in the state of Arizona, and is also licensed by the state of California to perform laboratory testing. Cyrex participates in CLIA approved proficiency testing methodologies assuring that the highest quality procedures and regulatory compliance are maintained within the laboratory. Cyrex follows the federal guidelines for the development of its laboratory assays in order to provide reliable and accurate results.

Congress passed the Clinical Laboratory Improvement Amendments (CLIA) in 1988, establishing quality standards for all laboratory testing to ensure the accuracy, reliability, and timeliness of patient test results regardless of where the test is performed.

Where is Cyrex Labs based?

Cyrex Lab's laboratory is located in Phoenix, Arizona. USA, and their HQ is in Irvine, California.

What are your labs 3 most popular or cutting edge tests?

The Multiple Food Immune Reactivity Screen (Array 10)

The Multiple Food Immune Reactivity Screen (Array 10) evaluates immune reactions to 180 raw, cooked or modified foods, lectins, aquaporins and artificial food additives, including meat glue, colorings, and gums.

Pathogen-Associated Immune Reactivity Screen (PAIRS)

Pathogen-Associated Immune Reactivity Screen (PAIRS) identifies an individual's response to specific pathogens that increase susceptibility to developing autoimmune reactions.

Multiple Autoimmune Reactivity Screen (Array 5)

Multiple Autoimmune Reactivity Screen (The Array 5) from Cyrex Laboratories assesses autoantibodies predictive for certain diseases. It determines potential tissue damage in various body organs, including cardiovascular, endocrine, joint, gastrointestinal, and neurological.

Have any notable clinical figures, bodies or publishers advocated using Cyrex Labs?

Dr Datis Kharrazian uses Cyrex panels in his clinical practice to better understand the environmental influence of the autoimmune disease found in his patients.

Datis also teaches about Cyrex panels in his highly esteemed practitioner education platform, The Kharrazian Institute. He is probably one of the world’s most recognisable clinicians and autoimmune disease educators.

Datis has been teaching Functional Medicine for nearly 20 years to thousands of healthcare professionals throughout the United States and Europe and has multiple professorial appointments at universities in the USA.

Do you have any positive testimonials’ about your lab from practitioners and patients? 

“As a practitioner of functional medicine, Cyrex tests have been a great asset in helping the complicated web of figuring out immune dysfunction. When there is a need to understand triggers to any pathology or possible solution to changing immune dysfunction, it is my go-to lab when routine labs are not enough. In addition, knowing the quality, accuracy and consistency of Cyrex labs gives me great confidence I’m getting the best results.”
John Ennen, DC

"I wanted to reach out and let you, and everybody else at Cyrex, that I feature your company prominently multiple times, in my new book, that just hit the shelves last week. I give descriptions of the type of testing Cyrex does, mention specific tests, contact information and overall make the case that you guys are the single best format for not only detecting autoimmunity but several other terribly important things. I highly suspect that it will bring even more customers and doctors your way. It has always been such a pleasure to work with you in finding answers for our patients and I am glad to share your gift with a greater audience."
Chris Chlebowski, DC

Has Cyrex Labs been involved with any clinical research?

Research is ongoing and led by Dr Vojdani and our scientific team.  Dr Vojdani has published more than 170 papers in peer reviewed literature and this continues to grow every year. Below are some of the fundamental papers he has published, that may inform your clinical practice:

The Role of Exposomes in the Pathophysiology of Autoimmune Diseases I: Toxic Chemicals and Food Vojdani A, Vojdani E. Pathophysiology. 2021 Dec 18;28(4):513-543. doi: 10.3390/pathophysiology28040034. PMID: 35366249; PMCID: PMC8830458.

The Role of Exposomes in the Pathophysiology of Autoimmune Diseases II: Pathogens Vojdani A, Vojdani E, Rosenberg AZ, Shoenfeld Y.. Pathophysiology. 2022 Jun 3;29(2):243-280. doi: 10.3390/pathophysiology29020020. PMID: 35736648; PMCID: PMC9231084.

Fluctuation of zonulin levels in blood vs stability of antibodies Vojdani A, Vojdani E, Kharrazian D. World J Gastroenterol. 2017 Aug 21;23(31):5669-5679. doi: 10.3748/wjg.v23.i31.5669. PMID: 28883692; PMCID: PMC5569281.

Immunological Reactivity Using Monoclonal and Polyclonal Antibodies of Autoimmune Thyroid Target Sites with Dietary Proteins - Kharrazian D, Herbert M, Vojdani A.. J Thyroid Res. 2017;2017:4354723. doi: 10.1155/2017/4354723. Epub 2017 Aug 15. PMID: 28894619; PMCID: PMC5574310.

Detection of Islet Cell Immune Reactivity with Low Glycemic Index Foods: Is This a Concern for Type 1 Diabetes? Kharrazian D, Herbert M, Vojdani A. J Diabetes Res. 2017;2017:4124967. doi: 10.1155/2017/4124967. Epub 2017 Jul 27. PMID: 28819632; PMCID: PMC5551512.

The prevalence of antibodies against wheat and milk proteins in blood donors and their contribution to neuroimmune reactivities Vojdani A, Kharrazian D, Mukherjee PS.. Nutrients. 2013 Dec 19;6(1):15-36. doi: 10.3390/nu6010015. PMID: 24451306; PMCID: PMC3916846.

Why did Cyrex Labs choose to partner with Regenerus labs to provide UK practitioners access to your services?

Michelle Clark, Vice President Worldwide Sales at Cyrex Labs

"When choosing a partner for international distribution, Regenerus was the obvious choice.

Regenerus' focus on practitioner education and the high standards they set for the tests they choose to partner with means we feel confident that the practitioners using our tests in the UK, Irelend and the EU will be supported in the decision making around test selection and also in appropriate interpretation of the tests, so that these practitioners in turn can use Cyrex panels for optimal outcomes in their clinical practice."