Description
Coeliac disease (CD) is often undiagnosed and is caused in genetically predisposed individuals by abnormal intestinal permeability and abnormal immune response to gluten, a protein complex found in wheat, barley, spelt and rye. The inflammatory autoimmune response damages the lining of the small bowel and is associated with diarrhoea, bloating, fatigue, nutritional deficiencies, and systemic autoimmune conditions. Gluten sensitivity can cause similar symptoms but without the same level of tissue damage. The Coeliac & Gluten Sensitivity profile from Doctor's Data helps differentiate between CD and gluten sensitivity by evaluating the serum titers of IgA and IgG for tissue transglutaminase, deamidated gliadin peptide, and gliadin.
Methodology
Chemiluminesent Immunoassay
When should I use
If the patient is taking steroids, immunosuppressant medications or other medications that may suppress antibodies please check if it is appropriate for them to test.
Patients who have persistent skin conditions (rash) or ataxia, idiopathic neurological conditions, autoimmune arthritis/ thyroiditis, unexplained weight loss or persistent gastrointestinal symptoms that are not associated with enteropathogens
Symptomatic individuals that have tested positive for the HLA DQ2/DQ8 genotypes
Patients with symptoms or symptom exacerbation with dietary gluten or re-introduction of gluten after a trial elimination of gluten
Individuals that have a first degree relative with a diagnosis of CD
Any child with a history of 3 or more antibiotic-treated cases of gastroenteritis while less than 6 months of age
Patients on a gluten-inclusive diet who have Type I diabetes, Multiple Sclerosis or schizophrenia
Individuals on a gluten-inclusive diet who have other laboratory evidence that may be associated with CD:
Elevated liver function tests
Bone demineralization
Evidence of impaired absorption of fat-soluble vitamins, iron, B12 or folic acid
Other Details
Other Tests to Consider:
IMM11A -Coeliac Profile (Finger Prick)
